IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils

evaluation of the correlation and reproducibility between histamine, il-4, and il-13 release from human basophils.

human  basophils play a key role in allergic diseases such as asthma and in a variety of  immunological disorders.  the  generation  of  il-4  and  il-13  can  be  induced  from basophil  by  ige-mediated   and   non-ige-mediated   mechanisms.  time   and   stimulus- dependent  differences  in  the  regulation  of  these  cytokines  could  have  relevance  to their biological effects. the aim o...

Detection of IL-4, IL-6 and IL-12 Serum Levels in Generalized Aggressive Periodontitis

Background: Periodontitis is a multifactorial chronic inflammatory disease characterized by destruction of tooth-supporting tissues. Environmental and genetic factors as well as the immune system participate in this process. Recent studies have attempted to elucidate the role of cytokine networks involved in periodontal diseases. Objective: To assess and compare the levels of IL-4, IL-6 and IL-...

Histamine potently suppresses human IL-12 and stimulates IL-10 production via H2 receptors.

IL-12 and IL-10, respectively, stimulate Th1 and Th2 immune responses. The development of some allergic reactions, infections, and tumors are associated with excessive histamine production and a shift toward Th2 responses. Here we address the possibility that this association is causally linked, at least in part, to modulation of IL-12 and IL-10 production by histamine. We report that histamine...

IL-12/IL-18-Dependent IFN-g Release by Murine Dendritic Cells

Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-gamma production by dendritic cells.

Mouse splenic dendritic cells (DCs) produce IFN-gamma in response to IL-12. In the present study, we analyzed effects of Th1 and Th2 cytokines on IFN-gamma production by DCs. IL-18 produced by DCs and macrophages acts in an autocrine manner and augments IL-12-induced IFN-gamma production by DCs as also observed in T and NK cells. Surprisingly, IL-4, a Th2 cytokine, also acts synergistically wit...